BioPipelineBench (Anthropic)
Agents execute bioinformatics workflows such as long-read sequence analysis, metagenome assembly and chromatin profiling with a bash tool.
In-house Anthropic evaluation. The tasks are not public.
- Made by
- Anthropic
- Released
- February 2026
- Kind
- Lab and data work
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Agent task
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4.8 #21 on the capability index
- Last in a system card
- May 2026
- Last model added
- May 2026
Claude Opus 4.8 leads with 87.7% among models released by May 2026
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in May 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- Claude Fable 5.2
-
Gemini 4 Carbon - GPT-6 Astra
- Claude Opus 5.5
- and 16 more
- 1 Claude Opus 4.8 87.7%
- 2 Claude Opus 4.6 53.1%
- 3 Claude Sonnet 4.6 52.1%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 4.8 | 87.7% | May 2026 | Lab model card | |
| 2 | Claude Opus 4.6 | 53.1% | Feb 2026 | Lab model card | |
| 3 | Claude Sonnet 4.6 | 52.1% | Feb 2026 | Lab model card |
2 models have held number one in labs’ own numbers since its release in February 2026
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
Anthropic’s own number for Claude Opus 4.8 passed 85% in May 2026
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| May 28, 2026 | Claude Opus 4.8 system card | 87.7 | BioPipelineBench Verified, only problems that passed external validation, bash tool, no extended thinking (8.16.1) | Capabilities |
| Feb 17, 2026 | Claude Sonnet 4.6 system card | 52.1 | Computational Biology, BioPipelineBench, no extended thinking (2.21.1) | Capabilities |
| Feb 5, 2026 | Claude Opus 4.6 system card | 53.1 | Computational Biology, BioPipelineBench, bash tool, no extended thinking (2.22) | Capabilities |
More in Science and reasoning
- GPQA Diamond In use 198 graduate-level 'Google-proof' multiple-choice questions in biology, chemistry and physics. Gemini 4 Carbon 96.5%
- Terminal-Bench-Science In use 70 scientific research-workflow tasks across five science areas, run in Harbor containers. Hidden tests give the resolution rate. GPT-6 Astra 68.1%
- FrontierScience In use Models solve physics, chemistry, and biology problems in an Olympiad track graded by short answer and a Research track graded by 10-point rubrics.
Intern-S2-397B 87% - BioMysteryBench In use Bioinformatics problems on anonymized real datasets that require real analysis with tools. Rubric-graded, with human-solvable and human-difficult splits. Claude Fable 5.2 83.7%
- HiPhO In use Models solve theory problems from 2024 and 2025 physics olympiad exams, some with diagrams. Official marking schemes grade answers and steps, mapped to medal levels. Gemini 3 Pro 78.3%
- LABBench2 In use 11 biology research sub-tasks (literature, figures, tables, patents, trials and more) with tool access. Macro-averaged accuracy. GPT-5.2 60.9%