Benchmark Almanac

LatchBio Capabilities v1.0

Claude Opus 5.5 58% leads since September 2026
Only in system cards

LatchBio cross-benchmark suite of agentic biological data analysis (transcriptomics, epigenomics, variants, pharmacology) with deterministic graders.

The V1 Capabilities score on benchmarks.bio is a weighted mean of 13 LatchBio benchmarks. They are the SpatialBench, scBench, EpiBench, VariantBench, MetagenomicsBench, TxBench, BioSecBench and OncologyBench sets. Legacy V0 scores are not comparable with V1. Fireworks lists the suite as BioBench.

Made by
LatchBio
Released
2026
Kind
Lab and data work
Level
Expert
Scored
Checked automatically
Answers
Short answer
Strongest model tested
GPT-6 Astra #3 on the capability index
Last in a system card
September 2026
Last model added
October 2026
Scores refreshed
November 12th, 2026
27
Models scored on its own leaderboard
1
System card reports it, from 1 lab

Claude Opus 5.5 leads with 58%

Best score per model from the benchmark's own leaderboard, read on November 12th, 2026. Where a model ran with several settings or harnesses, we keep its best.

27 models. Scroll sideways for the rest.

  1. 58.0 Claude Opus 5.5
  2. 54.2 Claude Sonnet 5.5
  3. 53.0 Claude Fable 5.1
  4. 52.4 Gemini 4 Argon
  5. 51.3 GPT-6 Astra
  6. 50.6 GPT-6.1 Sol
  7. 50.0 Claude Opus 5
  8. 47.4 Grok 4.6
  9. 47.4 Grok 4.7
  10. 46.7 GPT-6 Sol
  11. 45.3 Claude Opus 4.8
  12. 43.4 GPT-6.1 Terra
  13. 43.3 GPT-5.6 Sol
  14. 42.1 DeepSeek V4.1 Flash
  15. 41.9 GPT-5.5
  16. 40.9 Claude Sonnet 5
  17. 40.8 Gemini 3.7 Flash
  18. 38.6 Claude Opus 4.7
  19. 37.7 Gemini 3.8 Flash
  20. 37.2 GPT-6 Luna
  21. 36.4 Kimi K3
  22. 34.9 Mistral Large 4
  23. 33.6 GLM-5.3
  24. 33.5 GPT-5.6 Luna
  25. 31.5 Claude Sonnet 4.6
  26. 24.2 Nemotron 3 Ultra
  27. 14.4 Nemotron 3.5 Lightning 30B-A3B
  1. 1 Claude Opus 5.5 LSVP 58%
  2. 2 Claude Sonnet 5.5 54.2%
  3. 3 Claude Fable 5.1 LSVP 53%
  4. 4 Gemini 4 Argon 52.4%
  5. 5 GPT-6 Astra 51.3%
  6. 6 GPT-6.1 Sol 50.6%
  7. 7 Claude Opus 5 50%
  8. 8 Grok 4.6 47.4%
  9. 9 Grok 4.7 47.4%
  10. 10 GPT-6 Sol 46.7%
  11. 11 Claude Opus 4.8 45.3%
  12. 12 GPT-6.1 Terra 43.4%
  13. 13 GPT-5.6 Sol 43.3%
  14. 14 DeepSeek V4.1 Flash 42.1%
  15. 15 GPT-5.5 41.9%
  16. 16 Claude Sonnet 5 40.9%
  17. 17 Gemini 3.7 Flash 40.8%
  18. 18 Claude Opus 4.7 38.6%
  19. 19 Gemini 3.8 Flash 37.7%
  20. 20 GPT-6 Luna 37.2%
  21. 21 Kimi K3 36.4%
  22. 22 Mistral Large 4 34.9%
  23. 23 GLM-5.3 33.6%
  24. 24 GPT-5.6 Luna 33.5%
  25. 25 Claude Sonnet 4.6 31.5%
  26. 26 Nemotron 3 Ultra 24.2%
  27. 27 Nemotron 3.5 Lightning 30B-A3B 14.4%

Source: Official LatchBio Capabilities v1.0 leaderboard

#ModelScoreSettingDateSource
1 Claude Opus 5.5 58% LSVP, Pi Sep 2026 Official leaderboard
2 Claude Sonnet 5.5 54.2% Pi Sep 2026 Official leaderboard
3 Claude Fable 5.1 53% LSVP, Pi Sep 2026 Official leaderboard
4 Gemini 4 Argon 52.4% Pi Sep 2026 Official leaderboard
5 GPT-6 Astra 51.3% Pi Sep 2026 Official leaderboard
6 GPT-6.1 Sol 50.6% Pi Sep 2026 Official leaderboard
7 Claude Opus 5 50% Pi Jul 2026 Official leaderboard
8 Grok 4.6 47.4% Pi Aug 2026 Official leaderboard
9 Grok 4.7 47.4% Pi Sep 2026 Official leaderboard
10 GPT-6 Sol 46.7% Pi Sep 2026 Official leaderboard
11 Claude Opus 4.8 45.3% Pi May 2026 Official leaderboard
12 GPT-6.1 Terra 43.4% Pi Oct 2026 Official leaderboard
13 GPT-5.6 Sol 43.3% Pi Jul 2026 Official leaderboard
14 DeepSeek V4.1 Flash 42.1% Pi Sep 2026 Official leaderboard
15 GPT-5.5 41.9% Pi Apr 2026 Official leaderboard
16 Claude Sonnet 5 40.9% Pi Jun 2026 Official leaderboard
17 Gemini 3.7 Flash 40.8% Pi Aug 2026 Official leaderboard
18 Claude Opus 4.7 38.6% Pi Apr 2026 Official leaderboard
19 Gemini 3.8 Flash 37.7% Pi Sep 2026 Official leaderboard
20 GPT-6 Luna 37.2% Pi Sep 2026 Official leaderboard
21 Kimi K3 36.4% Pi Jul 2026 Official leaderboard
22 Mistral Large 4 34.9% Pi Oct 2026 Official leaderboard
23 GLM-5.3 33.6% Pi Aug 2026 Official leaderboard
24 GPT-5.6 Luna 33.5% Codex Jul 2026 Official leaderboard
25 Claude Sonnet 4.6 31.5% Pi Feb 2026 Official leaderboard
26 Nemotron 3 Ultra 24.2% Pi Jun 2026 Official leaderboard
27 Nemotron 3.5 Lightning 30B-A3B 14.4% Pi Aug 2026 Official leaderboard

Labs report scores for 1 model in their cards. We plot every source in the charts below.

7 models have held number one on the official leaderboard since its release in January 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic OpenAI
Own leaderboard 7 leaders
Claude Opus 5.5 58%

Source: Official LatchBio Capabilities v1.0 leaderboard

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Fable 5.1 Claude Opus 4.8 Claude Opus 4.7 Claude Sonnet 4.6 0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Opus 5

Sources: Official LatchBio Capabilities v1.0 leaderboard and labs’ model cards

Labs report it only in system cards

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.

One system card reports it

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
Sep 21, 2026 Grok 4.7 model card 44.5 LatchBio Capabilities v1.0, overall score (mean of 11 capability benchmarks), xhigh (5.2) Capabilities

One lab claim next to the leaderboard

Each score a lab reported for its own model, beside the same model's best score on the leaderboard. Gaps mostly come from different harnesses, effort levels and task subsets. Every benchmark.

Model Lab says Board says Gap
Grok 4.7 44.5% LatchBio Capabilities v1.0, overall score (mean of 11 capability benchmarks), xhigh (5.2) 47.4% Leaderboard, Pi −2.9 pts

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