Medicinal Chemistry (Anthropic)
Models see several real drug-discovery compounds and pick which had the highest or lowest measured ADME property. The set has 504 questions.
In-house Anthropic evaluation. The tasks are not public.
- Made by
- Anthropic
- Released
- September 2026
- Kind
- Research science
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Multiple choice
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 5.5 #4 on the capability index
- Last in a system card
- October 2026
- Last model added
- October 2026
Claude Sonnet 5.5 leads with 65.3%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 Claude Sonnet 5.5 65.3%
- 2 Claude Opus 5.5 63.5%
- 3 Claude Haiku 5.5 58%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Sonnet 5.5 | 65.3% | Sep 2026 | Lab model card | |
| 2 | Claude Opus 5.5 | 63.5% | Sep 2026 | Lab model card | |
| 3 | Claude Haiku 5.5 | 58% | Oct 2026 | Lab model card |
2 models have held number one in labs’ own numbers since its release in September 2026
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Oct 7, 2026 | Claude Haiku 5.5 system card | 58 | Medicinal chemistry, max effort (8.13.3) | Capabilities |
| Sep 28, 2026 | Claude Sonnet 5.5 system card | 65.3 | Medicinal Chemistry, 504 ADME questions (8.17.4, Figure 8.17.A) | Capabilities |
| Sep 22, 2026 | Claude Opus 5.5 system card | 63.5 | Medicinal chemistry, 504 ADME questions, no tools, max effort (8.17.4) | Capabilities |
More in Science and reasoning
- GPQA Diamond In use 198 graduate-level 'Google-proof' multiple-choice questions in biology, chemistry and physics.
Gemini 4 Carbon 96.5% - Terminal-Bench-Science In use 70 scientific research-workflow tasks across five science areas, run in Harbor containers. Hidden tests give the resolution rate. GPT-6 Astra 68.1%
- FrontierScience In use Models solve physics, chemistry, and biology problems in an Olympiad track graded by short answer and a Research track graded by 10-point rubrics.
Intern-S2-397B 87% - BioMysteryBench In use Bioinformatics problems on anonymized real datasets that require real analysis with tools. Rubric-graded, with human-solvable and human-difficult splits. Claude Fable 5.2 83.7%
- HiPhO In use Models solve theory problems from 2024 and 2025 physics olympiad exams, some with diagrams. Official marking schemes grade answers and steps, mapped to medal levels. Gemini 3 Pro 78.3%
- LABBench2 In use 11 biology research sub-tasks (literature, figures, tables, patents, trials and more) with tool access. Macro-averaged accuracy. GPT-5.2 60.9%