Structural Biology (Anthropic)
Models answer questions about a biomolecule's function from structural data and basic tools, in multiple-choice and open-ended variants.
In-house Anthropic evaluation. Cards report the two variants separately with no overall score.
- Made by
- Anthropic
- Released
- February 2026
- Kind
- Research science
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Agent task
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4.8 #21 on the capability index
- Last in a system card
- June 2026
- Last model added
- June 2026
Claude Opus 4.8 leads with 79%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 4.8 | 79% | May 2026 | Lab model card | |
| 2 | Claude Sonnet 5 | 69% | Jun 2026 | Lab model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
5 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Jun 30, 2026 | Claude Sonnet 5 system card | 69 | Structural biology, open-ended variant only, score 0.69 (8.14.3, Figure 8.14.6.A) | Capabilities |
| May 28, 2026 | Claude Opus 4.8 system card | 79 | Structural biology, open-ended questions only, no extended thinking (8.16.4) | Capabilities |
| Apr 16, 2026 | Claude Opus 4.7 system card | Structural biology, multiple-choice 98.3 and open-ended 74.0, no overall (8.13.3) | Capabilities | |
| Feb 17, 2026 | Claude Sonnet 4.6 system card | Structural Biology, multiple-choice 85.3 and open-ended 24.7, no overall (2.21.1) | Capabilities | |
| Feb 5, 2026 | Claude Opus 4.6 system card | Structural Biology, multiple-choice 88.3 and open-ended 28.4, no overall (2.22) | Capabilities |
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