Biology Model Refusal Evaluation
Models answer severe, dual-use and benign biology prompts. Scored as safe rate on harmful prompts and not over-refusing benign ones.
In-house OpenAI safeguard evaluation. Cards report rows with no overall number.
- Made by
- OpenAI
- Released
- June 2026
- Kind
- Refusing harmful requests
- Level
- Expert
- Scored
- Graded by a model
- Answers
- Open-ended
- Tasks
- Kept private
- Last in a system card
- November 2026
- Last model added
- November 2026
GPT-6 Cyber leads with 99.9%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 GPT-6 Cyber 99.9%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-6 Cyber | 99.9% | Nov 2026 | Lab model card |
OpenAI’s own number for GPT-6 Cyber passed 85% in November 2026
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
17 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Nov 5, 2026 | GPT-6 Cyber system card | 99.9 | Biology refusal evaluations, severe-risk requests, safe responses 99.87% (dual-use 98.27%, benign no unnecessary refusal 97.22%) | Bio and chem risk |
| Oct 29, 2026 | GPT-6 Luna system card addendum | Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) | Safety | |
| Oct 26, 2026 | GPT-6.1 Terra system card addendum | Biology Model Refusal Evaluation, severe 0.990, dual use 0.960, benign not over-refuse 0.982, no overall score (Table 31) | Safety | |
| Oct 7, 2026 | GPT-6 Sol system card addendum | Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) | Safety | |
| Oct 7, 2026 | GPT-6 Luna system card addendum | Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) | Safety | |
| Sep 29, 2026 | GPT-6.1 Sol system card addendum | Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 11) | Safety | |
| Sep 22, 2026 | GPT-6 Sol system card | Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 35) | Safety | |
| Sep 22, 2026 | GPT-6 Luna system card | Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 35) | Safety | |
| Sep 3, 2026 | GPT-6 Astra system card | Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 19) | Safety | |
| Aug 6, 2026 | GPT-5.6 Sol system card addendum | Biology Model Refusal Evaluation, severe and dual use rows (0.954, 0.945), no overall score (7.2.1.1) | Safety | |
| Aug 6, 2026 | GPT-5.6 Luna system card addendum | Biology Model Refusal Evaluation, severe and dual use rows (0.937, 0.928), no overall score (7.2.1.1) | Safety | |
| Jul 9, 2026 | GPT-5.6 Terra system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.950, 0.911, 0.978), no overall score (9.4.2.1) | Safety | |
| Jul 9, 2026 | GPT-5.6 Sol system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.943, 0.911, 0.989), no overall score (9.4.2.1) | Safety | |
| Jul 9, 2026 | GPT-5.6 Luna system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.946, 0.926, 0.989), no overall score (9.4.2.1) | Safety | |
| Jun 25, 2026 | GPT-5.6 Terra system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.950, 0.911, 0.978), no overall score (9.3.2.1) | Safety | |
| Jun 25, 2026 | GPT-5.6 Sol system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.943, 0.911, 0.989), no overall score (9.3.2.1) | Safety | |
| Jun 25, 2026 | GPT-5.6 Luna system card | Biology Model Refusal Evaluation, severe, dual use and benign rows (0.946, 0.926, 0.989), no overall score (9.3.2.1) | Safety |
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