Benchmark Almanac

Biology Model Refusal Evaluation

Only in system cards

Models answer severe, dual-use and benign biology prompts. Scored as safe rate on harmful prompts and not over-refusing benign ones.

In-house OpenAI safeguard evaluation. Cards report rows with no overall number.

Made by
OpenAI
Released
June 2026
Kind
Refusing harmful requests
Level
Expert
Scored
Graded by a model
Answers
Open-ended
Tasks
Kept private
Last in a system card
November 2026
Last model added
November 2026
1
Model scored in lab cards
17
System cards report it, from 1 lab

GPT-6 Cyber leads with 99.9%

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

  1. 1 GPT-6 Cyber 99.9%

Source: Labs’ model cards

#ModelScoreSettingDateSource
1 GPT-6 Cyber 99.9% Nov 2026 Lab model card

OpenAI’s own number for GPT-6 Cyber passed 85% in November 2026

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card
0% 20% 40% 60% 80% 100% 2027 Near the ceiling (85%) GPT-6 Cyber 0% 20% 40% 60% 80% 100% 2027 Near the ceiling (85%) GPT-6 Cyber

Source: Labs’ model cards

Labs report it only in system cards

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.

17 system cards report it, from 1 lab

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
Nov 5, 2026 GPT-6 Cyber system card 99.9 Biology refusal evaluations, severe-risk requests, safe responses 99.87% (dual-use 98.27%, benign no unnecessary refusal 97.22%) Bio and chem risk
Oct 29, 2026 GPT-6 Luna system card addendum Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) Safety
Oct 26, 2026 GPT-6.1 Terra system card addendum Biology Model Refusal Evaluation, severe 0.990, dual use 0.960, benign not over-refuse 0.982, no overall score (Table 31) Safety
Oct 7, 2026 GPT-6 Sol system card addendum Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) Safety
Oct 7, 2026 GPT-6 Luna system card addendum Biology Model Refusal Evaluation, severe and dual use rows, no overall score (Table 10) Safety
Sep 29, 2026 GPT-6.1 Sol system card addendum Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 11) Safety
Sep 22, 2026 GPT-6 Sol system card Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 35) Safety
Sep 22, 2026 GPT-6 Luna system card Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 35) Safety
Sep 3, 2026 GPT-6 Astra system card Biology Model Refusal Evaluation, severe, dual use and benign rows, no overall score (Table 19) Safety
Aug 6, 2026 GPT-5.6 Sol system card addendum Biology Model Refusal Evaluation, severe and dual use rows (0.954, 0.945), no overall score (7.2.1.1) Safety
Aug 6, 2026 GPT-5.6 Luna system card addendum Biology Model Refusal Evaluation, severe and dual use rows (0.937, 0.928), no overall score (7.2.1.1) Safety
Jul 9, 2026 GPT-5.6 Terra system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.950, 0.911, 0.978), no overall score (9.4.2.1) Safety
Jul 9, 2026 GPT-5.6 Sol system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.943, 0.911, 0.989), no overall score (9.4.2.1) Safety
Jul 9, 2026 GPT-5.6 Luna system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.946, 0.926, 0.989), no overall score (9.4.2.1) Safety
Jun 25, 2026 GPT-5.6 Terra system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.950, 0.911, 0.978), no overall score (9.3.2.1) Safety
Jun 25, 2026 GPT-5.6 Sol system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.943, 0.911, 0.989), no overall score (9.3.2.1) Safety
Jun 25, 2026 GPT-5.6 Luna system card Biology Model Refusal Evaluation, severe, dual use and benign rows (0.946, 0.926, 0.989), no overall score (9.3.2.1) Safety

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