Benchmark Almanac

RealmPathology

Claude Fable 5.1 78% leads since October 2026
Not in model cards

Models interpret real anatomic pathology reports and must not claim a diagnosis, stage or treatment the report does not support. Rubrics have 772 positive and 299 penalty criteria.

The current release rebuilt every rubric around four clinical failure modes and added penalties. micro1 says scores are not continuous with the earlier release. 13 models.

Made by
micro1
Released
October 2026
Kind
Medicine
Level
Expert
Scored
Graded by a model
Answers
Open-ended
Strongest model tested
GPT-6 Astra #3 on the capability index
Last model added
October 2026
Scores refreshed
November 12th, 2026
13
Models scored on its own leaderboard

Claude Fable 5.1 leads with 78%

Best score per model from the benchmark's own leaderboard, read on November 12th, 2026. Where a model ran with several settings or harnesses, we keep its best.

  1. 1 Claude Fable 5.1 max 78%
  2. 2 Claude Sonnet 5.5 max 77.3%
  3. 3 Claude Opus 5.5 max 77%
  4. 4 Muse Wonder max 76.4%
  5. 5 Muse Spark 1.3 xhigh 75.8%
  6. 6 Claude Opus 5 max 75.2%
  7. 7 Muse Spark 1.1 xhigh 74.9%
  8. 8 Grok 4.7 xhigh 73.1%
  9. 9 Grok 4.6 high 72.1%
  10. 10 Claude Sonnet 5 71.7%
  11. 11 GPT-6 Astra max 70.3%
  12. 12 GPT-6 Sol max 69.3%
  13. 13 Gemini 3.8 Flash high 66.3%

Source: Official RealmPathology leaderboard

#ModelScoreSettingDateSource
1 Claude Fable 5.1 78% max Sep 2026 Official leaderboard
2 Claude Sonnet 5.5 77.3% max Sep 2026 Official leaderboard
3 Claude Opus 5.5 77% max Sep 2026 Official leaderboard
4 Muse Wonder 76.4% max Oct 2026 Official leaderboard
5 Muse Spark 1.3 75.8% xhigh Sep 2026 Official leaderboard
6 Claude Opus 5 75.2% max Jul 2026 Official leaderboard
7 Muse Spark 1.1 74.9% xhigh Jul 2026 Official leaderboard
8 Grok 4.7 73.1% xhigh Sep 2026 Official leaderboard
9 Grok 4.6 72.1% high Aug 2026 Official leaderboard
10 Claude Sonnet 5 71.7% Jun 2026 Official leaderboard
11 GPT-6 Astra 70.3% max Sep 2026 Official leaderboard
12 GPT-6 Sol 69.3% max Sep 2026 Official leaderboard
13 Gemini 3.8 Flash 66.3% high Sep 2026 Official leaderboard

Number one over time

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic
Own leaderboard 1 leader

Source: Official RealmPathology leaderboard

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Best so far
0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Claude Fable 5.1 Claude Sonnet 5 0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Claude Fable 5.1 Claude Sonnet 5

Source: Official RealmPathology leaderboard

No lab model card reports it yet

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark.

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