AAV capsid packaging prediction
Models give the probability that each of 1,000 unpublished modified AAV capsid sequences assembles into a functional capsid. Scored as AUROC.
Built with Dyno Therapeutics for the CB-2 threshold. Run under five corpus and tool conditions.
- Released
- May 2026
- Kind
- Hazardous knowledge
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Prediction
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4.8 #21 on the capability index
- Last in a system card
- October 2026
- Last model added
- October 2026
Claude Opus 4.8 leads with 0.80
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 4.8 | 0.80 | May 2026 | Lab model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
6 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Oct 7, 2026 | Claude Haiku 5.5 system card | AAV capsid packaging prediction, AUROC under five conditions, chart without printed values (Figure 2.2.3.2.A) | Bio and chem risk | |
| Sep 28, 2026 | Claude Sonnet 5.5 system card | AAV capsid packaging prediction, AUROC under five conditions, chart without printed values (2.2.3.2, Figure 2.2.3.2.A) | Bio and chem risk | |
| Sep 22, 2026 | Claude Opus 5.5 system card | AAV capsid packaging prediction, AUROC under five conditions, chart without printed values. Text says within 0.01 of Mythos 5.1 and Opus 5, above ESM-2 alone at 0.699 (2.2.3.2.2, Figure 2.2.3.2.2.A) | Bio and chem risk | |
| Jul 24, 2026 | Claude Opus 5 system card | AAV capsid packaging prediction, AUROC under five resource conditions, chart without printed values. Text says it exceeds the naive ESM-2 baseline (2.2.5.2, Figure 2.2.5.2.A) | Bio and chem risk | |
| Jun 30, 2026 | Claude Sonnet 5 system card | AAV capsid packaging prediction, AUROC under five resource conditions, chart without printed values. Text: exceeds the naive ESM-2 baseline in the reasoning-only condition (2.2.5.2, Figure 2.2.5.2.A) | Bio and chem risk | |
| May 28, 2026 | Claude Opus 4.8 system card | 0.798 | AAV capsid packaging prediction, AUROC in the reasoning-only condition (no corpus, no PLM) that the notable-capability benchmark uses. ESM-2 provided 0.831, SwissProt 0.748, public AAV 0.783, SwissProt plus AAV 0.746 (Table 2.2.3.B, 2.2.5.2) | Bio and chem risk |
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