Bioweapons knowledge questions
Models answer 33 sensitive bioweapons questions written by Deloitte biosecurity staff. Answers are compared with novice, intermediate and expert baselines.
In-house Anthropic evaluation. The tasks are not public.
- Made by
- Anthropic
- Released
- February 2025
- Kind
- Hazardous knowledge
- Level
- Expert
- Scored
- Graded by people
- Answers
- Short answer
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4 #108 on the capability index
- Last in a system card
- May 2025
- Last model added
- May 2025
3 models share the top score of 51.5% among models released by May 2025
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in May 2025, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- Claude Fable 5.2
-
Gemini 4 Carbon - GPT-6 Astra
- Claude Opus 5.5
- and 16 more
- 1 Claude 3.7 Sonnet 51.5%
- 2 Claude Opus 4 51.5%
- 3 Claude Sonnet 4 51.5%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude 3.7 Sonnet | 51.5% | Feb 2025 | Lab model card | |
| 2 | Claude Opus 4 | 51.5% | May 2025 | Lab model card | |
| 3 | Claude Sonnet 4 | 51.5% | May 2025 | Lab model card |
Number one over time
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| May 22, 2025 | Claude Sonnet 4 system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than experts (7.2.4.5) | Bio and chem risk |
| May 22, 2025 | Claude Opus 4 system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than experts (7.2.4.5) | Bio and chem risk |
| Feb 24, 2025 | Claude 3.7 Sonnet system card | 51.5 | Bioweapons knowledge questions, answered 17/33 questions better than domain experts (7.1.4, Figure 17) | Bio and chem risk |
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