Creative biology
Models answer questions about unusual biology needed to engineer harmless biological agents, a weak proxy for novel weapon design.
SecureBio question set run by Anthropic. The questions are not public.
- Made by
- Anthropic
- Released
- May 2025
- Kind
- Hazardous knowledge
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Short answer
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4.6 #37 on the capability index
- Last in a system card
- February 2026
- Last model added
- February 2026
Claude Opus 4.6 leads with 60.3% among models released by February 2026
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
The newest model with a score here came out in February 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- Claude Fable 5.2
-
Gemini 4 Carbon - GPT-6 Astra
- Claude Opus 5.5
- and 16 more
- 1 Claude Opus 4.6 60.3%
- 2 Claude Sonnet 4.6 59.3%
- 3 Claude Opus 4.5 52.4%
- 4 Claude Sonnet 4.5 48.8%
- 5 Claude Opus 4.1 48%
- 6 Claude Opus 4 45%
- 7 Claude Sonnet 4 37%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 4.6 | 60.3% | Feb 2026 | Lab model card | |
| 2 | Claude Sonnet 4.6 | 59.3% | Feb 2026 | Lab model card | |
| 3 | Claude Opus 4.5 | 52.4% | Nov 2025 | Lab model card | |
| 4 | Claude Sonnet 4.5 | 48.8% | Sep 2025 | Lab model card | |
| 5 | Claude Opus 4.1 | 48% | Aug 2025 | Lab model card | |
| 6 | Claude Opus 4 | 45% | May 2025 | Lab model card | |
| 7 | Claude Sonnet 4 | 37% | May 2025 | Lab model card |
5 models have held number one in labs’ own numbers since its release in May 2025
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
7 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Feb 17, 2026 | Claude Sonnet 4.6 system card | 59.3 | Creative biology automated evaluation, score 0.593 (6.2.2.4) | Bio and chem risk |
| Feb 5, 2026 | Claude Opus 4.6 system card | 60.3 | Creative Biology Automated Evaluations, score 0.603 (8.2.4.8) | Bio and chem risk |
| Nov 24, 2025 | Claude Opus 4.5 system card | 52.4 | Creative biology score 0.524 (7.2.4.5) | Bio and chem risk |
| Sep 29, 2025 | Claude Sonnet 4.5 system card | 48.8 | Creative biology mean score 0.488 (Figure 9.2.4.5.A). Text gives 0.48 ± 0.08 and best of 30 attempts 0.79 (9.2.4.5) | Bio and chem risk |
| Aug 5, 2025 | Claude Opus 4.1 system card addendum | 48 | Creative biology, score 0.48 ± 0.09 (6.3.1.1) | Bio and chem risk |
| May 22, 2025 | Claude Sonnet 4 system card | 37 | Creative biology, mean score 0.37 ± 0.08. Best of 30 attempts 0.74 (7.2.4.8) | Bio and chem risk |
| May 22, 2025 | Claude Opus 4 system card | 45 | Creative biology, mean score 0.45 ± 0.08. Best of 30 attempts 0.81 (7.2.4.8) | Bio and chem risk |
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