Creative Biology Uplift Trial (Anthropic)
Participants with molecular biology PhDs write reports on novel biological workflows with or without model access. Expert graders score each report.
In-house Anthropic human uplift trial with twenty participants over three days. Results compare the model group with an internet-only control.
- Made by
- Anthropic
- Released
- February 2026
- Kind
- Hazardous knowledge
- Level
- Expert
- Scored
- Graded by people
- Answers
- Open-ended
- Tasks
- Kept private
- Strongest model tested
- Claude Opus 4.6 #37 on the capability index
- Last in a system card
- February 2026
- Last model added
- February 2026
Claude Opus 4.6 leads with 16.4
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude Opus 4.6 | 16.4 | Feb 2026 | Lab model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
One system card reports it
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Feb 5, 2026 | Claude Opus 4.6 system card | 16.4 | Creative Biology Uplift Trial, mean score of the model-assisted group 16.4 +/- 20.9 vs control 8.8 +/- 10.2, about 2x uplift, values printed on chart (Figure 8.2.4.4.A) | Bio and chem risk |
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