Benchmark Almanac

MetagenomicsBench

Claude Opus 5.5 62.7% leads since September 2026
Not in model cards

Agents analyze microbial communities from shotgun, amplicon, long-read and spatial metagenomics data. A grader checks the biological result.

Part of LatchBio's BioBench suite on benchmarks.bio. The V1 set has 100 evaluations. Release month is the GitHub repo creation month.

Made by
LatchBio
Released
September 2026
Kind
Genomics and life sciences
Level
Expert
Scored
Checked automatically
Answers
Agent task
Tasks
Public, plus a private test set
Strongest model tested
GPT-6 Astra #3 on the capability index
Last model added
October 2026
Scores refreshed
November 12th, 2026
26
Models scored on its own leaderboard

Claude Opus 5.5 leads with 62.7%

Best score per model from the benchmark's own leaderboard, read on November 12th, 2026. Where a model ran with several settings or harnesses, we keep its best.

26 models. Scroll sideways for the rest.

  1. 62.7 Claude Opus 5.5
  2. 61.7 Claude Fable 5.1
  3. 60.0 Claude Sonnet 5.5
  4. 54.0 Claude Opus 5
  5. 50.0 Claude Opus 4.8
  6. 49.7 GPT-6 Astra
  7. 48.7 Grok 4.7
  8. 45.7 GPT-6.1 Sol
  9. 42.3 Claude Sonnet 5
  10. 42.3 Gemini 4 Argon
  11. 42.0 Grok 4.6
  12. 42.0 GPT-6 Sol
  13. 38.7 GPT-6.1 Terra
  14. 38.0 DeepSeek V4.1 Flash
  15. 35.3 Claude Opus 4.7
  16. 31.7 Gemini 3.7 Flash
  17. 31.3 GPT-5.6 Sol
  18. 31.0 GPT-6 Luna
  19. 28.3 Claude Sonnet 4.6
  20. 27.3 Kimi K3
  21. 27.3 GLM-5.3
  22. 26.7 Gemini 3.8 Flash
  23. 26.3 Mistral Large 4
  24. 24.3 GPT-5.6 Luna
  25. 16.3 Nemotron 3 Ultra
  26. 7.67 Nemotron 3.5 Lightning 30B-A3B
  1. 1 Claude Opus 5.5 LSVP 62.7%
  2. 2 Claude Fable 5.1 LSVP 61.7%
  3. 3 Claude Sonnet 5.5 60%
  4. 4 Claude Opus 5 54%
  5. 5 Claude Opus 4.8 50%
  6. 6 GPT-6 Astra 49.7%
  7. 7 Grok 4.7 48.7%
  8. 8 GPT-6.1 Sol 45.7%
  9. 9 Claude Sonnet 5 42.3%
  10. 10 Gemini 4 Argon 42.3%
  11. 11 Grok 4.6 42%
  12. 12 GPT-6 Sol 42%
  13. 13 GPT-6.1 Terra 38.7%
  14. 14 DeepSeek V4.1 Flash 38%
  15. 15 Claude Opus 4.7 35.3%
  16. 16 Gemini 3.7 Flash 31.7%
  17. 17 GPT-5.6 Sol 31.3%
  18. 18 GPT-6 Luna 31%
  19. 19 Claude Sonnet 4.6 28.3%
  20. 20 Kimi K3 27.3%
  21. 21 GLM-5.3 27.3%
  22. 22 Gemini 3.8 Flash 26.7%
  23. 23 Mistral Large 4 26.3%
  24. 24 GPT-5.6 Luna 24.3%
  25. 25 Nemotron 3 Ultra 16.3%
  26. 26 Nemotron 3.5 Lightning 30B-A3B 7.67%

Source: Official MetagenomicsBench leaderboard

#ModelScoreSettingDateSource
1 Claude Opus 5.5 62.7% LSVP, Claude Code Sep 2026 Official leaderboard
2 Claude Fable 5.1 61.7% LSVP, Pi Sep 2026 Official leaderboard
3 Claude Sonnet 5.5 60% Claude Code Sep 2026 Official leaderboard
4 Claude Opus 5 54% Pi Jul 2026 Official leaderboard
5 Claude Opus 4.8 50% Claude Code May 2026 Official leaderboard
6 GPT-6 Astra 49.7% Codex Sep 2026 Official leaderboard
7 Grok 4.7 48.7% Pi Sep 2026 Official leaderboard
8 GPT-6.1 Sol 45.7% Pi Sep 2026 Official leaderboard
9 Claude Sonnet 5 42.3% Pi Jun 2026 Official leaderboard
10 Gemini 4 Argon 42.3% Pi Sep 2026 Official leaderboard
11 Grok 4.6 42% Grok Build Aug 2026 Official leaderboard
12 GPT-6 Sol 42% Pi Sep 2026 Official leaderboard
13 GPT-6.1 Terra 38.7% Pi Oct 2026 Official leaderboard
14 DeepSeek V4.1 Flash 38% Pi Sep 2026 Official leaderboard
15 Claude Opus 4.7 35.3% Pi Apr 2026 Official leaderboard
16 Gemini 3.7 Flash 31.7% Pi Aug 2026 Official leaderboard
17 GPT-5.6 Sol 31.3% Pi Jul 2026 Official leaderboard
18 GPT-6 Luna 31% Codex Sep 2026 Official leaderboard
19 Claude Sonnet 4.6 28.3% Claude Code Feb 2026 Official leaderboard
20 Kimi K3 27.3% Pi Jul 2026 Official leaderboard
21 GLM-5.3 27.3% Pi Aug 2026 Official leaderboard
22 Gemini 3.8 Flash 26.7% Pi Sep 2026 Official leaderboard
23 Mistral Large 4 26.3% Pi Oct 2026 Official leaderboard
24 GPT-5.6 Luna 24.3% Codex Jul 2026 Official leaderboard
25 Nemotron 3 Ultra 16.3% Pi Jun 2026 Official leaderboard
26 Nemotron 3.5 Lightning 30B-A3B 7.67% Pi Aug 2026 Official leaderboard

2 models have held number one on the official leaderboard since its release in September 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

Anthropic
Own leaderboard 2 leaders
Claude Opus 5.5 62.7%

Source: Official MetagenomicsBench leaderboard

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Best so far
0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Opus 5 Claude Opus 4.7 Claude Sonnet 4.6 0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 Claude Opus 5

Source: Official MetagenomicsBench leaderboard

No lab model card reports it yet

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark.

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