ReproBAIT
Agents independently reproduce biological AI models from published scientific papers. Scored as success rate.
Third-party SecureBio evaluation reported in OpenAI system cards.
- Made by
- SecureBio
- Kind
- Genomics and life sciences
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Agent task
- Strongest model tested
- GPT-6 Astra #3 on the capability index
- Last in a system card
- September 2026
- Last model added
- September 2026
GPT-5.6 Sol leads with 85%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 GPT-5.6 Sol 85%
- 2 GPT-6 Astra 83%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-5.6 Sol | 85% | Jun 2026 | Lab model card | |
| 2 | GPT-6 Astra | 83% | Sep 2026 | Lab model card |
Number one over time
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
OpenAI’s own number for GPT-5.6 Sol passed 85% in June 2026
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
3 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Sep 3, 2026 | GPT-6 Astra system card | 83 | SecureBio ReproBAIT, share of published performance reached, helpful-only checkpoint, six tasks (10.1.1.4) | Bio and chem risk |
| Jul 9, 2026 | GPT-5.6 Sol system card | 85 | SecureBio ReproBAIT, railfree variant of GPT-5.6 (9.1.1.8) | Bio and chem risk |
| Jun 25, 2026 | GPT-5.6 Sol system card | 85 | SecureBio ReproBAIT, railfree variant of GPT-5.6 (9.1.1.8) | Bio and chem risk |
More in Biology and chemistry
- GeneBench Pro In use Agents analyze messy simulated genomics and biology datasets to estimate a decision-relevant quantity across 129 problems. Scored automatically against known answers. GPT-5.6 Sol 31.5%
- SUPERChem In use Models solve 500 expert-written chemistry reasoning problems, offered in multimodal and text-only forms. Expert solution paths also allow a reasoning path score.
Tencent Hy4 preview 66.4% - LifeSciBench In use Models complete 750 expert-written life science research tasks, often with attached figures, tables, or sequence files. Graded against expert rubrics as score and pass rate. GPT-Rosalind-6 61.3%
- MedChemBench (OpenAI) In use Models answer chemistry questions from an OpenAI internal set, grouped with OpenAI's life science research evaluations. OpenAI has not published the task format. GPT-Rosalind-6 49.6%
- ProtocolQA Open-Ended In use Models correct errors in published lab protocols using open-ended questions adapted from LAB-Bench ProtocolQA. Scored as pass@1. GPT-6 Cyber 47.2%
- MolecularIQ In use Models answer questions about molecular graphs, such as counting, indexing and constrained generation, and a symbolic checker verifies each answer. gpt-oss-120b 47.5%