Benchmark Almanac

scBench-Long

Claude Opus 5.5 36.9% leads since September 2026
Not in model cards

Agents run long single-cell RNA-seq analyses that need sustained empirical work and biological reasoning.

Part of LatchBio's BioBench suite on benchmarks.bio. The V1 set has 22 evaluations. Release month is the GitHub repo creation month.

Made by
LatchBio
Released
June 2026
Kind
Genomics and life sciences
Level
Expert
Scored
Checked automatically
Answers
Agent task
Tasks
Public, plus a private test set
Strongest model tested
GPT-6 Astra #3 on the capability index
Last model added
October 2026
Scores refreshed
November 12th, 2026
27
Models scored on its own leaderboard

Claude Opus 5.5 leads with 36.9%

Best score per model from the benchmark's own leaderboard, read on November 12th, 2026. Where a model ran with several settings or harnesses, we keep its best.

27 models. Scroll sideways for the rest.

  1. 36.9 Claude Opus 5.5
  2. 31.8 Claude Sonnet 5.5
  3. 29.6 GPT-5.6 Sol
  4. 28.4 GPT-6 Sol
  5. 28.4 Gemini 4 Argon
  6. 27.3 Claude Opus 5
  7. 27.3 GPT-6 Astra
  8. 26.7 GPT-6.1 Sol
  9. 25.6 Claude Fable 5.1
  10. 21.6 GPT-5.5
  11. 21.0 Claude Opus 4.8
  12. 19.9 Gemini 3.8 Flash
  13. 18.8 Gemini 3.7 Flash
  14. 18.8 GPT-6.1 Terra
  15. 16.5 Grok 4.6
  16. 15.9 Claude Sonnet 5
  17. 14.8 DeepSeek V4.1 Flash
  18. 14.2 Kimi K3
  19. 13.1 GPT-5.6 Luna
  20. 11.9 GPT-6 Luna
  21. 11.4 Claude Opus 4.7
  22. 11.4 Grok 4.7
  23. 10.2 Claude Sonnet 4.6
  24. 10.2 GLM-5.3
  25. 10.2 Mistral Large 4
  26. 3.03 Nemotron 3 Ultra
  27. 0.0 Nemotron 3.5 Lightning 30B-A3B
  1. 1 Claude Opus 5.5 LSVP 36.9%
  2. 2 Claude Sonnet 5.5 31.8%
  3. 3 GPT-5.6 Sol 29.6%
  4. 4 GPT-6 Sol 28.4%
  5. 5 Gemini 4 Argon 28.4%
  6. 6 Claude Opus 5 27.3%
  7. 7 GPT-6 Astra 27.3%
  8. 8 GPT-6.1 Sol 26.7%
  9. 9 Claude Fable 5.1 LSVP 25.6%
  10. 10 GPT-5.5 21.6%
  11. 11 Claude Opus 4.8 21%
  12. 12 Gemini 3.8 Flash 19.9%
  13. 13 Gemini 3.7 Flash 18.8%
  14. 14 GPT-6.1 Terra 18.8%
  15. 15 Grok 4.6 16.5%
  16. 16 Claude Sonnet 5 15.9%
  17. 17 DeepSeek V4.1 Flash 14.8%
  18. 18 Kimi K3 14.2%
  19. 19 GPT-5.6 Luna 13.1%
  20. 20 GPT-6 Luna 11.9%
  21. 21 Claude Opus 4.7 11.4%
  22. 22 Grok 4.7 11.4%
  23. 23 Claude Sonnet 4.6 10.2%
  24. 24 GLM-5.3 10.2%
  25. 25 Mistral Large 4 10.2%
  26. 26 Nemotron 3 Ultra 3.03%
  27. 27 Nemotron 3.5 Lightning 30B-A3B 0%

Source: Official scBench-Long leaderboard

#ModelScoreSettingDateSource
1 Claude Opus 5.5 36.9% LSVP, Pi Sep 2026 Official leaderboard
2 Claude Sonnet 5.5 31.8% Claude Code Sep 2026 Official leaderboard
3 GPT-5.6 Sol 29.6% Codex Jul 2026 Official leaderboard
4 GPT-6 Sol 28.4% Pi Sep 2026 Official leaderboard
5 Gemini 4 Argon 28.4% Pi Sep 2026 Official leaderboard
6 Claude Opus 5 27.3% Pi Jul 2026 Official leaderboard
7 GPT-6 Astra 27.3% Pi Sep 2026 Official leaderboard
8 GPT-6.1 Sol 26.7% Pi Sep 2026 Official leaderboard
9 Claude Fable 5.1 25.6% LSVP, Pi Sep 2026 Official leaderboard
10 GPT-5.5 21.6% Pi Apr 2026 Official leaderboard
11 Claude Opus 4.8 21% Claude Code May 2026 Official leaderboard
12 Gemini 3.8 Flash 19.9% Pi Sep 2026 Official leaderboard
13 Gemini 3.7 Flash 18.8% Pi Aug 2026 Official leaderboard
14 GPT-6.1 Terra 18.8% Codex Oct 2026 Official leaderboard
15 Grok 4.6 16.5% Pi Aug 2026 Official leaderboard
16 Claude Sonnet 5 15.9% Pi Jun 2026 Official leaderboard
17 DeepSeek V4.1 Flash 14.8% Pi Sep 2026 Official leaderboard
18 Kimi K3 14.2% Pi Jul 2026 Official leaderboard
19 GPT-5.6 Luna 13.1% Pi Jul 2026 Official leaderboard
20 GPT-6 Luna 11.9% Codex Sep 2026 Official leaderboard
21 Claude Opus 4.7 11.4% Claude Code Apr 2026 Official leaderboard
22 Grok 4.7 11.4% Pi Sep 2026 Official leaderboard
23 Claude Sonnet 4.6 10.2% Claude Code Feb 2026 Official leaderboard
24 GLM-5.3 10.2% Pi Aug 2026 Official leaderboard
25 Mistral Large 4 10.2% Pi Oct 2026 Official leaderboard
26 Nemotron 3 Ultra 3.03% Pi Jun 2026 Official leaderboard
27 Nemotron 3.5 Lightning 30B-A3B 0% Pi Aug 2026 Official leaderboard

3 models have held number one on the official leaderboard since its release in June 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

OpenAI Anthropic
Own leaderboard 3 leaders
Claude Opus 5.5 36.9%

Source: Official scBench-Long leaderboard

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Best so far
0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 GPT-5.6 Sol GPT-5.5 Claude Opus 4.7 0% 20% 40% 60% 80% 100% 2026 2027 Near the ceiling (85%) Claude Opus 5.5 GPT-5.6 Sol

Source: Official scBench-Long leaderboard

No lab model card reports it yet

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark.

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