Biochemistry knowledge improvement
Models answer biochemistry tasks on structures, mutation thermodynamics, reaction products, arrow pushing and DNA phylogeny. Scored as reward@4.
OpenAI Preparedness evaluation. A 30 point jump over the previous model triggers further investigation.
- Made by
- OpenAI
- Released
- April 2026
- Kind
- Genomics and life sciences
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Short answer
- Tasks
- Kept private
- Strongest model tested
- GPT-5.5 Pro #14 on the capability index
- Last in a system card
- April 2026
- Last model added
- April 2026
GPT-5.5 Pro leads with 39.3%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1 GPT-5.5 Pro 39.3%
- 2 GPT-5.5 32.3%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | GPT-5.5 Pro | 39.3% | Apr 2026 | Lab model card | |
| 2 | GPT-5.5 | 32.3% | Apr 2026 | Lab model card |
Scores over time
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
2 system cards report it, from 1 lab
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Apr 23, 2026 | GPT-5.5 system card | 32.3 | Biochemistry knowledge improvement over GPT-5.4-thinking, reward@4 (Table 11) | Bio and chem risk |
| Apr 23, 2026 | GPT-5.5 Pro system card | 39.3 | Biochemistry knowledge improvement over GPT-5.4-thinking, reward@4, GPT-5.5 Pro (Table 11) | Bio and chem risk |
More in Biology and chemistry
- GeneBench Pro In use Agents analyze messy simulated genomics and biology datasets to estimate a decision-relevant quantity across 129 problems. Scored automatically against known answers. GPT-5.6 Sol 31.5%
- SUPERChem In use Models solve 500 expert-written chemistry reasoning problems, offered in multimodal and text-only forms. Expert solution paths also allow a reasoning path score.
Tencent Hy4 preview 66.4% - LifeSciBench In use Models complete 750 expert-written life science research tasks, often with attached figures, tables, or sequence files. Graded against expert rubrics as score and pass rate. GPT-Rosalind-6 61.3%
- MedChemBench (OpenAI) In use Models answer chemistry questions from an OpenAI internal set, grouped with OpenAI's life science research evaluations. OpenAI has not published the task format. GPT-Rosalind-6 49.6%
- ProtocolQA Open-Ended In use Models correct errors in published lab protocols using open-ended questions adapted from LAB-Bench ProtocolQA. Scored as pass@1. GPT-6 Cyber 47.2%
- MolecularIQ In use Models answer questions about molecular graphs, such as counting, indexing and constrained generation, and a symbolic checker verifies each answer. gpt-oss-120b 47.5%