Benchmark Almanac

Hard-negative protein binding prediction

GPT-5.6 Sol 7.60% leads since June 2026
Only in system cards

Agents with structure files and tools pick the one true binder among five similar designed proteins. Scored as pass@4.

OpenAI Preparedness evaluation on proprietary binding data. The concern threshold is 50 percent.

Made by
OpenAI
Released
April 2026
Kind
Genomics and life sciences
Level
Research frontier
Scored
Checked automatically
Answers
Agent task
Tasks
Kept private
Strongest model tested
GPT-6 Astra #3 on the capability index
Last in a system card
September 2026
Last model added
September 2026
4
Models scored in lab cards
6
System cards report it, from 1 lab

GPT-5.6 Sol leads with 7.60% among models released by September 2026

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

The newest model with a score here came out in September 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:

  1. 7.60 GPT-5.6 Sol
  2. 1.48 GPT-5.5
  3. 0.0 GPT-5.5 Pro
  4. 0.0 GPT-6 Astra
  1. 1 GPT-5.6 Sol 7.60%
  2. 2 GPT-5.5 1.48%
  3. 3 GPT-5.5 Pro 0%
  4. 4 GPT-6 Astra 0%

Source: Labs’ model cards

#ModelScoreSettingDateSource
1 GPT-5.6 Sol 7.60% Jun 2026 Lab model card
2 GPT-5.5 1.48% Apr 2026 Lab model card
3 GPT-5.5 Pro 0% Apr 2026 Lab model card
4 GPT-6 Astra 0% Sep 2026 Lab model card

2 models have held number one in labs’ own numbers since its release in April 2026

Lab claims count from the day the card came out, independent runs from the model’s release.

OpenAI
Lab claims Not tested since Sep 2026
GPT-5.6 Sol 7.60%

Source: Labs’ model cards

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) GPT-5.6 Sol GPT-5.5 0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) GPT-5.6 Sol

Source: Labs’ model cards

Labs report it only in system cards

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.

6 system cards report it, from 1 lab

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
Sep 3, 2026 GPT-6 Astra system card 0 Hard-negative protein binding prediction, pass@4, retiring evaluation (Table 16) Bio and chem risk
Aug 6, 2026 GPT-5.6 Sol system card addendum 5.27 Hard-negative protein binding prediction, pass@4, GPT-5.6 Sol (August) (7.1.1.5) Bio and chem risk
Jul 9, 2026 GPT-5.6 Sol system card 7.6 Hard-negative protein binding prediction, pass@4 (Table 2, 9.1.1.6) Bio and chem risk
Jun 25, 2026 GPT-5.6 Sol system card 7.6 Hard-negative protein binding prediction, pass@4 (Table 2, 9.1.1.6) Bio and chem risk
Apr 23, 2026 GPT-5.5 system card 1.48 Hard negative protein binding prediction, pass@4, corrected August 19, 2026 (Table 12) Bio and chem risk
Apr 23, 2026 GPT-5.5 Pro system card 0 Hard negative protein binding prediction, pass@4, GPT-5.5 Pro (Table 12) Bio and chem risk

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