LAB-Bench CloningScenarios
Models answer multiple-choice questions about multi-step molecular cloning workflows. CloningScenarios subset of LAB-Bench.
33 public questions on multi-plasmid cloning workflows. PhD researchers score about 60%. LABBench2 carries a 14-task open-response cloning config.
- Made by
- FutureHouse
- Released
- July 2024
- Kind
- Lab protocols
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Multiple choice
- Tasks
- All public
- Strongest model tested
-
Gemini 3 Pro #55 on the capability index
- Last in a launch post
- March 2026, dropped after it saturated
- Last model added
- April 2026
- Scores refreshed
- November 12th, 2026
In the authors’ words
There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and reasoning on textbook-style science questions, but few if any benchmarks are designed to evaluate language model performance on practical tasks required for scientific research, such as literature search, protocol planning, and data analysis. As a step toward building such benchmarks, we introduce the Language Agent Biology Benchmark (LAB-Bench), a broad dataset of over 2,400 multiple choice questions for evaluating AI systems on a range of practical biology research capabilities, including recall and reasoning over literature, interpretation of figures, access and navigation of databases, and comprehension and manipulation of DNA and protein sequences. Importantly, in contrast to previous scientific benchmarks, we expect that an AI system that can achieve consistently high scores on the more difficult LAB-Bench tasks would serve as a useful assistant for researchers in areas such as literature search and molecular cloning. As an initial assessment of the emergent scientific task capabilities of frontier language models, we measure performance of several against our benchmark and report results compared to human expert biology researchers. We will continue to update and expand LAB-Bench over time, and expect it to serve as a useful tool in the development of automated research systems going forward. A public subset of LAB-Bench is available for use at the following URL: https://huggingface.co/datasets/futurehouse/lab-bench
Gemini 3 Pro leads with 94.2% among models released by February 2026
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
Claude 3.5 Sonnet leads with 28% across all independent runs
Best score per model across the official leaderboard, Epoch AI’s own runs and any board Epoch AI copied. Each bar and row names its source.
Gemini 3 Pro leads with 94.2%, claims included
Best score per model from every source, including labs’ own numbers and claims Epoch AI collected from reports and papers. Labs pick their own settings, so a claim can beat an independent run of the same model.
The newest model with a score here came out in February 2026, and nobody has reported a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:
- Claude Fable 5.2
-
Gemini 4 Carbon
- GPT-6 Astra
- Claude Opus 5.5
- and 16 more
- 1
Gemini 3 Pro 94.2%
- 2 Claude Opus 4.5 75.8%
- 3 Grok 4.20 67%
- 4 Claude Sonnet 4.5 66.7%
- 5 Claude Opus 4.1 56%
- 6
Gemini 2.5 Pro Jun 2025 53%
- 7 Grok 4.1 46%
- 8 Claude Haiku 4.5 45%
- 9
Gemini 2.5 Pro Mar 2025 44.1%
- 10
Gemini 2.5 Flash Jun 2025 44%
- 11 o1-mini 39.4%
- 12 o1-preview 36.4%
Source: Labs’ model cards
- 1 Claude 3.5 Sonnet 28%
- 2 Claude 3 Opus 27%
- 3 Claude 3 Haiku 26%
Source: Official LAB-Bench CloningScenarios leaderboard
- 1
Gemini 3 Pro 94.2%
- 2 Claude Opus 4.5 75.8%
- 3 Grok 4.20 67%
- 4 Claude Sonnet 4.5 66.7%
- 5 Claude Opus 4.1 56%
- 6
Gemini 2.5 Pro Jun 2025 53%
- 7 Grok 4.1 46%
- 8 Claude Haiku 4.5 45%
- 9
Gemini 2.5 Pro Mar 2025 44.1%
- 10
Gemini 2.5 Flash Jun 2025 44%
- 11 o1-mini 39.4%
- 12 o1-preview 36.4%
- 13 Claude 3.5 Sonnet 28%
- 14 Claude 3 Opus 27%
- 15 Claude 3 Haiku 26%
Sources: Labs’ model cards and official LAB-Bench CloningScenarios leaderboard
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | | 94.2% | Nov 2025 | Lab model card | |
| 2 | Claude Opus 4.5 | 75.8% | Nov 2025 | Lab model card | |
| 3 | Grok 4.20 | 67% | Mar 2026 | Lab model card | |
| 4 | Claude Sonnet 4.5 | 66.7% | Sep 2025 | Lab model card | |
| 5 | Claude Opus 4.1 | 56% | Aug 2025 | Lab model card | |
| 6 | | 53% | Jul 2025 | Lab model card | |
| 7 | Grok 4.1 | 46% | Nov 2025 | Lab model card | |
| 8 | Claude Haiku 4.5 | 45% | Oct 2025 | Lab model card | |
| 9 | | 44.1% | Apr 2025 | Lab model card | |
| 10 | | 44% | Jul 2025 | Lab model card | |
| 11 | o1-mini | 39.4% | Sep 2024 | Lab model card | |
| 12 | o1-preview | 36.4% | Sep 2024 | Lab model card |
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | Claude 3.5 Sonnet | 28% | Jun 2024 | Official leaderboard | |
| 2 | Claude 3 Opus | 27% | Feb 2024 | Official leaderboard | |
| 3 | Claude 3 Haiku | 26% | Mar 2024 | Official leaderboard |
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | | 94.2% | Nov 2025 | Lab model card | |
| 2 | Claude Opus 4.5 | 75.8% | Nov 2025 | Lab model card | |
| 3 | Grok 4.20 | 67% | Mar 2026 | Lab model card | |
| 4 | Claude Sonnet 4.5 | 66.7% | Sep 2025 | Lab model card | |
| 5 | Claude Opus 4.1 | 56% | Aug 2025 | Lab model card | |
| 6 | | 53% | Jul 2025 | Lab model card | |
| 7 | Grok 4.1 | 46% | Nov 2025 | Lab model card | |
| 8 | Claude Haiku 4.5 | 45% | Oct 2025 | Lab model card | |
| 9 | | 44.1% | Apr 2025 | Lab model card | |
| 10 | | 44% | Jul 2025 | Lab model card | |
| 11 | o1-mini | 39.4% | Sep 2024 | Lab model card | |
| 12 | o1-preview | 36.4% | Sep 2024 | Lab model card | |
| 13 | Claude 3.5 Sonnet | 28% | Jun 2024 | Official leaderboard | |
| 14 | Claude 3 Opus | 27% | Feb 2024 | Official leaderboard | |
| 15 | Claude 3 Haiku | 26% | Mar 2024 | Official leaderboard |
The benchmark's own leaderboard has 7 entries, 3 of them models we track. Switch the scores above to rank them together.
6 models have held number one in labs’ own numbers since its release in July 2024 Number one over time 7 models have held number one with claims included since its release in July 2024
Lab claims count from the day the card came out, independent runs from the model’s release. We draw one row each for the benchmark’s own leaderboard and what labs claim in their cards.
Sources: Official LAB-Bench CloningScenarios leaderboard and labs’ model cards
Google DeepMind’s own number for Gemini 3 Pro passed 85% in November 2025
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Sources: Official LAB-Bench CloningScenarios leaderboard and labs’ model cards
Labs headline it less often now, last in March 2026
Launch posts from every lab that has listed it, one tick per post. Tall colored ticks include it, and short gray ones leave it out.
| Date | Launch post | Score | As the post writes it |
|---|---|---|---|
| Mar 9, 2026 | Grok 4.20 | 67 | CloningScenarios, accuracy 0.67, Grok 4.2 SA, Table 4 |
15 system cards report it, from 4 labs
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Apr 7, 2026 | Grok 4.20 model card | 67 | CloningScenarios, accuracy 0.67, Grok 4.2 SA, Table 4 | Safety |
| Nov 24, 2025 | Claude Opus 4.5 system card | 75.8 | LAB-Bench Cloning Scenarios, 10-shot, extended thinking, no tools, max across snapshots 0.758 (7.2.4.4) | Bio and chem risk |
| Nov 18, 2025 | | 94.2 | LAB-Bench Cloning Scenarios (N=33), mean solve rate, shuffled answer choices (Figure 1) | Bio and chem risk |
| Nov 17, 2025 | Grok 4.1 model card | 46 | CloningScenarios, accuracy 0.46, Grok 4.1 Thinking (Table 4) | Bio and chem risk |
| Oct 15, 2025 | Claude Haiku 4.5 system card | 45 | LAB-Bench Cloning Scenarios, k-shots=10, score 0.45 (6.2.3.1) | Bio and chem risk |
| Sep 29, 2025 | Claude Sonnet 4.5 system card | 66.7 | LAB-Bench Cloning Scenarios, 10-shot, no tools, score 0.667 (Figure 9.2.4.4.A) | Bio and chem risk |
| Aug 5, 2025 | Claude Opus 4.1 system card addendum | 56 | LAB-Bench subset Cloning Scenarios 0.56 (6.3.1.2) | Bio and chem risk |
| Jul 7, 2025 | | 53 | LAB-Bench Cloning Scenarios (N=33), mean solve rate (Figure 9) | Bio and chem risk |
| Jul 7, 2025 | | 44 | LAB-Bench Cloning Scenarios (N=33), mean solve rate (Figure 9) | Bio and chem risk |
| May 22, 2025 | Claude Sonnet 4 system card | LAB-Bench Cloning Scenarios, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) | Bio and chem risk | |
| May 22, 2025 | Claude Opus 4 system card | LAB-Bench Cloning Scenarios, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) | Bio and chem risk | |
| Apr 28, 2025 | | 44.1 | Cloning Scenarios (N=33), mean solve rate over 100 shuffled runs (Figure 1) | Bio and chem risk |
| Feb 24, 2025 | Claude 3.7 Sonnet system card | LabBench subset CloningScenarios, 0 and 5 shots with Bo1 to Bo10, 32k thinking, chart without printed values (Figures 18 and 19) | Bio and chem risk | |
| Sep 12, 2024 | o1-preview system card | 36.4 | LAB-Bench: Cloning Scenarios, pass rate cons@32, o1-preview (post-mitigation), printed chart label (4.3.5) | Bio and chem risk |
| Sep 12, 2024 | o1-mini system card | 39.4 | LAB-Bench: Cloning Scenarios, pass rate cons@32, o1-mini (post-mitigation), printed chart label (4.3.5) | Bio and chem risk |
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