Benchmark Almanac

SHP2 Protein Function Prediction

GPT-6 Astra 0.40 leads since September 2026
Only in system cards

Models predict held-out assay measurements for single amino acid variants of SHP2. Scored as mean R squared over three assay datasets.

OpenAI Critical bio capability evaluation. The Critical threshold is 0.60.

Made by
OpenAI
Released
September 2026
Kind
Genomics and life sciences
Level
Research frontier
Scored
Checked automatically
Answers
Prediction
Tasks
Kept private
Strongest model tested
GPT-6 Astra #3 on the capability index
Last in a system card
October 2026
Last model added
October 2026
6
Models scored in lab cards
8
System cards report it, from 1 lab

GPT-6 Astra leads with 0.40

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

  1. 0.40 GPT-6 Astra
  2. 0.38 GPT-Rosalind-6
  3. 0.37 GPT-6.1 Terra
  4. 0.33 GPT-6.1 Sol
  5. 0.27 GPT-6 Sol
  6. 0.21 GPT-6 Luna
  1. 1 GPT-6 Astra 0.40
  2. 2 GPT-Rosalind-6 0.38
  3. 3 GPT-6.1 Terra 0.37
  4. 4 GPT-6.1 Sol 0.33
  5. 5 GPT-6 Sol 0.27
  6. 6 GPT-6 Luna 0.21

Source: Labs’ model cards

#ModelScoreSettingDateSource
1 GPT-6 Astra 0.40 Sep 2026 Lab model card
2 GPT-Rosalind-6 0.38 Oct 2026 Lab model card
3 GPT-6.1 Terra 0.37 Oct 2026 Lab model card
4 GPT-6.1 Sol 0.33 Sep 2026 Lab model card
5 GPT-6 Sol 0.27 Sep 2026 Lab model card
6 GPT-6 Luna 0.21 Oct 2026 Lab model card

Number one over time

Lab claims count from the day the card came out, independent runs from the model’s release.

OpenAI
Lab claims 1 leader
GPT-6 Astra 0.40

Source: Labs’ model cards

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

Reported by the lab in its model card
0.20 0.30 0.40 2027 0.20 0.30 0.40 2027

Source: Labs’ model cards

Labs report it only in system cards

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.

8 system cards report it, from 1 lab

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
Oct 30, 2026 GPT-Rosalind-6 system card 0.38 SHP2 Protein Function Prediction, mean R² Bio and chem risk
Oct 29, 2026 GPT-6 Luna system card addendum 0.21 SHP2 Protein Function Prediction, mean R² (Table 9) Bio and chem risk
Oct 26, 2026 GPT-6.1 Terra system card addendum 0.37 SHP2 Protein Function Prediction, mean R² across three assay datasets (table, 9.0.1.2) Bio and chem risk
Oct 7, 2026 GPT-6 Sol system card addendum 0.23 SHP2 Protein Function Prediction, mean R² (Table 9) Bio and chem risk
Oct 7, 2026 GPT-6 Luna system card addendum 0.13 SHP2 Protein Function Prediction, mean R² (Table 9) Bio and chem risk
Sep 29, 2026 GPT-6.1 Sol system card addendum 0.332 SHP2 Protein Function Prediction, mean R² (9.1.1.2) Bio and chem risk
Sep 22, 2026 GPT-6 Sol system card 0.273 SHP2 Protein Function Prediction, mean R² (Table 34, A.8.1.1.2) Bio and chem risk
Sep 3, 2026 GPT-6 Astra system card 0.4 SHP2 Protein Function Prediction, mean R² (helpful-only 0.35) (Table 13) Bio and chem risk

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