Benchmark Almanac

LABBench2 SeqQA2

Gemini 3 Pro 52.5% leads since February 2026
Not in model cards

Models reason about DNA and protein sequences and answer in open response. The SeqQA2 subtask of LABBench2.

400 tasks in the seqqa2 config of the LABBench2 dataset. Open response replaces multiple choice, so scores are not comparable with the LAB-Bench subtask.

Released
February 2026
Kind
Genomics and life sciences
Level
Expert
Scored
Checked automatically
Answers
Short answer
Tasks
Public, plus a private test set
Strongest model tested
GPT-5.2 Pro #31 on the capability index
Last model added
February 2026
Scores refreshed
November 12th, 2026

In the authors’ words

Optimism for accelerating scientific discovery with AI continues to grow. Current applications of AI in scientific research range from training dedicated foundation models on scientific data to agentic autonomous hypothesis generation systems to AI-driven autonomous labs. The need to measure progress of AI systems in scientific domains correspondingly must not only accelerate, but increasingly shift focus to more real-world capabilities. Beyond rote knowledge and even just reasoning to actually measuring the ability to perform meaningful work. Prior work introduced the Language Agent Biology Benchmark LAB-Bench as an initial attempt at measuring these abilities. Here we introduce an evolution of that benchmark, LABBench2, for measuring real-world capabilities of AI systems performing useful scientific tasks. LABBench2 comprises nearly 1,900 tasks and is, for the most part, a continuation of LAB-Bench, measuring similar capabilities but in more realistic contexts. We evaluate performance of current frontier models, and show that while abilities measured by LAB-Bench and LABBench2 have improved substantially, LABBench2 provides a meaningful jump in difficulty (model-specific accuracy differences range from -26% to -46% across subtasks) and underscores continued room for performance improvement. LABBench2 continues the legacy of LAB-Bench as a de facto benchmark for AI scientific research capabilities and we hope that it continues to help advance development of AI tools for these core research functions. To facilitate community use and development, we provide the task dataset at https://huggingface.co/datasets/futurehouse/labbench2 and a public eval harness at https://github.com/EdisonScientific/labbench2.

Abstract of LABBench2: An Improved Benchmark for AI Systems Performing Biology Research (arXiv:2604.09554, CC0)
5
Models scored on its own leaderboard

Gemini 3 Pro leads with 52.5% among models released by February 2026

Best score per model from the benchmark's own leaderboard, read on November 12th, 2026. Where a model ran with several settings or harnesses, we keep its best. Every run is in the next chart.

The newest model with a score here came out in February 2026, and nobody has tested a newer one. Among the 20 highest-ranked models on the capability index, these have no score yet:

  1. 1 Gemini 3 Pro mode inject; tools,high 52.5%
  2. 2 GPT-5.2 mode inject; tools,high 49.5%
  3. 3 GPT-5.2 Pro mode inject; tools,high 46.3%
  4. 4 Claude Opus 4.5 mode file; tools,high 45.5%
  5. 5 Claude Opus 4.6 mode inject; tools,high 44.3%

Source: Official LABBench2 SeqQA2 leaderboard

#ModelScoreSettingDateSource
1 Gemini 3 Pro 52.5% mode inject; tools,high, LABBench2 tools Nov 2025 Official leaderboard
2 GPT-5.2 49.5% mode inject; tools,high, LABBench2 tools Dec 2025 Official leaderboard
3 GPT-5.2 Pro 46.3% mode inject; tools,high, LABBench2 tools Dec 2025 Official leaderboard
4 Claude Opus 4.5 45.5% mode file; tools,high, LABBench2 tools Nov 2025 Official leaderboard
5 Claude Opus 4.6 44.3% mode inject; tools,high, LABBench2 tools Feb 2026 Official leaderboard

More effort adds a median 37 points

Models the leaderboard ran at two or more effort levels. We don’t have enough cost data here to say what the extra effort costs.

Lowest effort to highest, light to dark
Gemini 3 Pro LABBench2 tools
mode retrie… mode file; …
52.5%
GPT-5.2 LABBench2 tools
mode retrie… mode file; … mode inject…
49.5%
Gemini 3 Pro LABBench2
mode retrie… mode file
49.2%
GPT-5.2 Pro LABBench2 tools
mode retrie… mode inject…
46.3%
Claude Opus 4.5 LABBench2 tools
mode inject…
45.5%
GPT-5.2 Pro LABBench2
mode retrie… mode inject
44.5%
Claude Opus 4.6 LABBench2 tools
mode file; …
44.3%
Claude Opus 4.6 LABBench2
mode retrie… mode file mode inject
34.5%
Claude Opus 4.5 LABBench2
mode retrie… mode file
30.7%
GPT-5.2 LABBench2
mode retrie… mode inject
25.5%

Source: Official LABBench2 SeqQA2 leaderboard

ModelEffortHarnessScoreCost per taskOutput tokens
Gemini 3 Pro mode inject; tools,high LABBench2 tools 52.5% 3,600
Gemini 3 Pro mode file; tools,high LABBench2 tools 52.2% 3,400
GPT-5.2 mode inject; tools,high LABBench2 tools 49.5% 2,000
Gemini 3 Pro mode inject LABBench2 49.2% 512
Gemini 3 Pro mode file LABBench2 48.7% 466
GPT-5.2 Pro mode inject; tools,high LABBench2 tools 46.3% 5,100
Claude Opus 4.5 mode file; tools,high LABBench2 tools 45.5% 1,600
GPT-5.2 Pro mode inject LABBench2 44.5% 2,500
GPT-5.2 mode file; tools,high LABBench2 tools 44.3% 4,000
Claude Opus 4.6 mode inject; tools,high LABBench2 tools 44.3% 5,400
Claude Opus 4.6 mode file; tools,high LABBench2 tools 44% 2,500
Claude Opus 4.5 mode inject; tools,high LABBench2 tools 42.7% 2,600
Claude Opus 4.6 mode inject LABBench2 34.5% 527
Claude Opus 4.5 mode inject LABBench2 30.7% 433
Claude Opus 4.5 mode file LABBench2 27% 310
Claude Opus 4.6 mode file LABBench2 26% 414
GPT-5.2 mode file LABBench2 25.5% 14
GPT-5.2 mode inject LABBench2 25.3% 15
Gemini 3 Pro mode retrieve LABBench2 12% 408
Gemini 3 Pro mode retrieve; tools,high LABBench2 tools 12% 582
GPT-5.2 mode retrieve LABBench2 9.50% 53
GPT-5.2 Pro mode retrieve; tools,high LABBench2 tools 9.50% 12,900
GPT-5.2 mode retrieve; tools,high LABBench2 tools 8.00% 15,500
GPT-5.2 Pro mode retrieve LABBench2 7.50% 2,000
Claude Opus 4.6 mode retrieve LABBench2 3.00% 134
Claude Opus 4.5 mode retrieve LABBench2 2.00% 167

Number one over time

Lab claims count from the day the card came out, independent runs from the model’s release.

Google DeepMind
Own leaderboard Not tested since Feb 2026
Gemini 3 Pro 52.5%

Source: Official LABBench2 SeqQA2 leaderboard

Scores over time

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard
0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Gemini 3 Pro 0% 20% 40% 60% 80% 100% 2026 Near the ceiling (85%) Gemini 3 Pro

Source: Official LABBench2 SeqQA2 leaderboard

No lab model card reports it yet

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark.

Versions

We switch the top row to each new version when it comes out. Open it for one row per version. An old version stays in play while people still test it, so whoever first takes it past 85% gets credit for closing it out.

Google DeepMind Anthropic Meta
LABBench2 SeqQA2 Not tested since Feb 2026
Gemini 3 Pro 52.5%
LAB-Bench SeqQA Passed 85% in Nov 2025, by Gemini 3 Pro
LABBench2 SeqQA2 Not tested since Feb 2026
Gemini 3 Pro 52.5%

Sources: Official leaderboards and labs’ model cards

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