LAB-Bench SeqQA
Models answer multiple-choice questions that require DNA and protein sequence manipulation. SeqQA subset of LAB-Bench.
Anthropic reports LAB-Bench subsets separately in its RSP bio sections.
- Made by
- FutureHouse
- Released
- July 2024
- Kind
- Genomics and life sciences
- Level
- Expert
- Scored
- Checked automatically
- Answers
- Multiple choice
- Tasks
- All public
- Strongest model tested
-
Muse Spark 1.3 #26 on the capability index
- Last in a system card
- October 2026
- Last model added
- October 2026
In the authors’ words
There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and reasoning on textbook-style science questions, but few if any benchmarks are designed to evaluate language model performance on practical tasks required for scientific research, such as literature search, protocol planning, and data analysis. As a step toward building such benchmarks, we introduce the Language Agent Biology Benchmark (LAB-Bench), a broad dataset of over 2,400 multiple choice questions for evaluating AI systems on a range of practical biology research capabilities, including recall and reasoning over literature, interpretation of figures, access and navigation of databases, and comprehension and manipulation of DNA and protein sequences. Importantly, in contrast to previous scientific benchmarks, we expect that an AI system that can achieve consistently high scores on the more difficult LAB-Bench tasks would serve as a useful assistant for researchers in areas such as literature search and molecular cloning. As an initial assessment of the emergent scientific task capabilities of frontier language models, we measure performance of several against our benchmark and report results compared to human expert biology researchers. We will continue to update and expand LAB-Bench over time, and expect it to serve as a useful tool in the development of automated research systems going forward. A public subset of LAB-Bench is available for use at the following URL: https://huggingface.co/datasets/futurehouse/lab-bench
Muse Spark 1.1 leads with 98.2%
Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.
- 1
Muse Spark 1.1 98.2%
- 2
Muse Spark 97.3%
- 3
Muse Wonder Full 95.6%
- 4
Muse Spark 1.3 95.2%
- 5
Gemini 3 Pro 87.6%
- 6 Claude Opus 4.5 85.2%
- 7 Claude Sonnet 4.5 78%
- 8
Gemini 2.5 Pro Jun 2025 71%
- 9 Claude Opus 4.1 71%
- 10 Claude Haiku 4.5 66%
- 11
Gemini 2.5 Pro Mar 2025 63.9%
- 12
Gemini 2.5 Flash Jun 2025 58%
Source: Labs’ model cards
| # | Model | Score | Setting | Date | Source |
|---|---|---|---|---|---|
| 1 | | 98.2% | Jul 2026 | Lab model card | |
| 2 | | 97.3% | Jun 2026 | Lab model card | |
| 3 | | 95.6% | Oct 2026 | Lab model card | |
| 4 | | 95.2% | Oct 2026 | Lab model card | |
| 5 | | 87.6% | Nov 2025 | Lab model card | |
| 6 | Claude Opus 4.5 | 85.2% | Nov 2025 | Lab model card | |
| 7 | Claude Sonnet 4.5 | 78% | Sep 2025 | Lab model card | |
| 8 | | 71% | Jul 2025 | Lab model card | |
| 9 | Claude Opus 4.1 | 71% | Aug 2025 | Lab model card | |
| 10 | Claude Haiku 4.5 | 66% | Oct 2025 | Lab model card | |
| 11 | | 63.9% | Apr 2025 | Lab model card | |
| 12 | | 58% | Jul 2025 | Lab model card |
6 models have held number one in labs’ own numbers since its release in July 2024
Lab claims count from the day the card came out, independent runs from the model’s release.
Source: Labs’ model cards
Google DeepMind’s own number for Gemini 3 Pro passed 85% in November 2025
All the scores we have, one dot each, so a model tested at several settings appears more than once.
Source: Labs’ model cards
Labs report it only in system cards
We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.
15 system cards report it, from 3 labs
Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.
| Date | Document | Score | As the document writes it | Section |
|---|---|---|---|---|
| Oct 23, 2026 | | 95.2 | LAB-Bench SeqQA (agentic, Python tool) accuracy, Muse Spark 1.3 (API) (Table 1, Figure 2) | Bio and chem risk |
| Oct 12, 2026 | | 95.6 | Lab-Bench (v1) SeqQA + tools (CBRN Capability Evaluations table, section 4) | Bio and chem risk |
| Jul 9, 2026 | | 98.2 | LAB-Bench SeqQA (agentic), Muse Spark 1.1 Helpful (Table 1, Figure 3) | Bio and chem risk |
| Jun 12, 2026 | | 97.3 | LAB-Bench SeqQA (tools), Python tool access (Table 1, Figure 3) | Bio and chem risk |
| Nov 24, 2025 | Claude Opus 4.5 system card | 85.2 | LAB-Bench SeqQA, 10-shot, extended thinking, no tools, max across snapshots 0.8517 (7.2.4.4) | Bio and chem risk |
| Nov 18, 2025 | | 87.6 | LAB-Bench SeqQA (N=600), mean solve rate, shuffled answer choices (Figure 1) | Bio and chem risk |
| Oct 15, 2025 | Claude Haiku 4.5 system card | 66 | LAB-Bench SeqQA, k-shots=10, score 0.66 (6.2.3.1) | Bio and chem risk |
| Sep 29, 2025 | Claude Sonnet 4.5 system card | 78 | LAB-Bench SeqQA (Sequence QA), 10-shot, no tools, score 0.780 (Figure 9.2.4.4.A) | Bio and chem risk |
| Aug 5, 2025 | Claude Opus 4.1 system card addendum | 71 | LAB-Bench subset SeqQA 0.71 (6.3.1.2) | Bio and chem risk |
| Jul 7, 2025 | | 71 | LAB-Bench SeqQA (N=600), mean solve rate (Figure 9) | Bio and chem risk |
| Jul 7, 2025 | | 58 | LAB-Bench SeqQA (N=600), mean solve rate (Figure 9) | Bio and chem risk |
| May 22, 2025 | Claude Sonnet 4 system card | LAB-Bench SeqQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) | Bio and chem risk | |
| May 22, 2025 | Claude Opus 4 system card | LAB-Bench SeqQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) | Bio and chem risk | |
| Apr 28, 2025 | | 63.9 | SeqQA (N=600), mean solve rate over 100 shuffled runs (Figure 1) | Bio and chem risk |
| Feb 24, 2025 | Claude 3.7 Sonnet system card | LabBench subset SeqQA, 0 and 5 shots with Bo1 to Bo10, 32k thinking, chart without printed values (Figures 18 and 19) | Bio and chem risk |
Versions
We switch the top row to each new version when it comes out. Open it for one row per version. An old version stays in play while people still test it, so whoever first takes it past 85% gets credit for closing it out.
Sources: Official leaderboards and labs’ model cards
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