Benchmark Almanac

LAB-Bench ProtocolQA

Claude Opus 4.5 90.7% leads since November 2025
Claude 3 Opus 52% leads since July 2024
Claude Opus 4.5 90.7% leads since November 2025
Only in system cards

Models find and fix errors in lab protocols in multiple-choice form. ProtocolQA subset of LAB-Bench.

Anthropic reports LAB-Bench subsets separately in its RSP bio sections.

Made by
FutureHouse
Released
July 2024
Kind
Lab protocols
Level
Expert
Scored
Checked automatically
Answers
Multiple choice
Tasks
All public
Strongest model tested
Muse Spark 1.3 #26 on the capability index
Last in a system card
October 2026
Last model added
October 2026
Scores refreshed
November 12th, 2026

In the authors’ words

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and reasoning on textbook-style science questions, but few if any benchmarks are designed to evaluate language model performance on practical tasks required for scientific research, such as literature search, protocol planning, and data analysis. As a step toward building such benchmarks, we introduce the Language Agent Biology Benchmark (LAB-Bench), a broad dataset of over 2,400 multiple choice questions for evaluating AI systems on a range of practical biology research capabilities, including recall and reasoning over literature, interpretation of figures, access and navigation of databases, and comprehension and manipulation of DNA and protein sequences. Importantly, in contrast to previous scientific benchmarks, we expect that an AI system that can achieve consistently high scores on the more difficult LAB-Bench tasks would serve as a useful assistant for researchers in areas such as literature search and molecular cloning. As an initial assessment of the emergent scientific task capabilities of frontier language models, we measure performance of several against our benchmark and report results compared to human expert biology researchers. We will continue to update and expand LAB-Bench over time, and expect it to serve as a useful tool in the development of automated research systems going forward. A public subset of LAB-Bench is available for use at the following URL: https://huggingface.co/datasets/futurehouse/lab-bench

Abstract of LAB-Bench: Measuring Capabilities of Language Models for Biology Research (arXiv:2407.10362, CC0)
16
Models scored in lab cards
19
System cards report it, from 5 labs

Claude Opus 4.5 leads with 90.7%

Best score per model as labs report them in their own cards. Labs pick their own settings, so these compare less cleanly than independent runs.

Claude 3 Opus leads with 52% across all independent runs

Best score per model across the official leaderboard, Epoch AI’s own runs and any board Epoch AI copied. Each bar and row names its source.

Claude Opus 4.5 leads with 90.7%, claims included

Best score per model from every source, including labs’ own numbers and claims Epoch AI collected from reports and papers. Labs pick their own settings, so a claim can beat an independent run of the same model.

  1. 1 Claude Opus 4.5 90.7%
  2. 2 Muse Wonder Full 89%
  3. 3 Muse Spark 1.1 88%
  4. 4 Muse Spark 1.3 87.7%
  5. 5 Gemini 3 Pro 87.4%
  6. 6 Muse Spark 87.3%
  7. 7 Claude Sonnet 4.5 83.3%
  8. 8 o1-preview 81%
  9. 9 Grok 4.1 79%
  10. 10 Grok 4.20 79%
  11. 11 Gemini 2.5 Pro Jun 2025 74%
  12. 12 Gemini 2.5 Pro Mar 2025 69%
  13. 13 Claude Opus 4.1 69%
  14. 14 Claude Haiku 4.5 69%
  15. 15 o1-mini 67.6%
  16. 16 Gemini 2.5 Flash Jun 2025 64%

Source: Labs’ model cards

Source: Official LAB-Bench ProtocolQA leaderboard

#ModelScoreSettingDateSource
1 Claude Opus 4.5 90.7% Nov 2025 Lab model card
2 Muse Wonder Full 89% Oct 2026 Lab model card
3 Muse Spark 1.1 88% Jul 2026 Lab model card
4 Muse Spark 1.3 87.7% Oct 2026 Lab model card
5 Gemini 3 Pro 87.4% Nov 2025 Lab model card
6 Muse Spark 87.3% Jun 2026 Lab model card
7 Claude Sonnet 4.5 83.3% Sep 2025 Lab model card
8 o1-preview 81% Sep 2024 Lab model card
9 Grok 4.1 79% Nov 2025 Lab model card
10 Grok 4.20 79% Apr 2026 Lab model card
11 Gemini 2.5 Pro Jun 2025 74% Jul 2025 Lab model card
12 Gemini 2.5 Pro Mar 2025 69% Apr 2025 Lab model card
13 Claude Opus 4.1 69% Aug 2025 Lab model card
14 Claude Haiku 4.5 69% Oct 2025 Lab model card
15 o1-mini 67.6% Sep 2024 Lab model card
16 Gemini 2.5 Flash Jun 2025 64% Jul 2025 Lab model card
#ModelScoreSettingDateSource
1 Claude 3 Opus 52% Feb 2024 Official leaderboard
2 Claude 3.5 Sonnet 48% Jun 2024 Official leaderboard
3 Claude 3 Haiku 45% Mar 2024 Official leaderboard
#ModelScoreSettingDateSource
1 Claude Opus 4.5 90.7% Nov 2025 Lab model card
2 Muse Wonder Full 89% Oct 2026 Lab model card
3 Muse Spark 1.1 88% Jul 2026 Lab model card
4 Muse Spark 1.3 87.7% Oct 2026 Lab model card
5 Gemini 3 Pro 87.4% Nov 2025 Lab model card
6 Muse Spark 87.3% Jun 2026 Lab model card
7 Claude Sonnet 4.5 83.3% Sep 2025 Lab model card
8 o1-preview 81% Sep 2024 Lab model card
9 Grok 4.1 79% Nov 2025 Lab model card
10 Grok 4.20 79% Apr 2026 Lab model card
11 Gemini 2.5 Pro Jun 2025 74% Jul 2025 Lab model card
12 Gemini 2.5 Pro Mar 2025 69% Apr 2025 Lab model card
13 Claude Opus 4.1 69% Aug 2025 Lab model card
14 Claude Haiku 4.5 69% Oct 2025 Lab model card
15 o1-mini 67.6% Sep 2024 Lab model card
16 Gemini 2.5 Flash Jun 2025 64% Jul 2025 Lab model card
17 Claude 3 Opus 52% Feb 2024 Official leaderboard
18 Claude 3.5 Sonnet 48% Jun 2024 Official leaderboard
19 Claude 3 Haiku 45% Mar 2024 Official leaderboard

The benchmark's own leaderboard has 7 entries, 3 of them models we track. Switch the scores above to rank them together.

4 models have held number one in labs’ own numbers since its release in July 2024 Number one over time 5 models have held number one with claims included since its release in July 2024

Lab claims count from the day the card came out, independent runs from the model’s release. We draw one row each for the benchmark’s own leaderboard and what labs claim in their cards.

Anthropic OpenAI Google DeepMind
Own leaderboard Not tested since Jul 2024
Lab claims Passed 85% in Nov 2025, by Gemini 3 Pro

Sources: Official LAB-Bench ProtocolQA leaderboard and labs’ model cards

Google DeepMind’s own number for Gemini 3 Pro passed 85% in November 2025

All the scores we have, one dot each, so a model tested at several settings appears more than once.

On the benchmark’s own leaderboard Reported by the lab in its model card Best so far
0% 20% 40% 60% 80% 100% 2024 2025 2026 2027 Near the ceiling (85%) Claude Opus 4.5 Claude Sonnet 4.5 o1-preview Claude 3 Opus 0% 20% 40% 60% 80% 100% 2024 2025 2026 2027 Near the ceiling (85%) Claude Opus 4.5 Claude Sonnet 4.5

Sources: Official LAB-Bench ProtocolQA leaderboard and labs’ model cards

Labs report it only in system cards

We read the headline results of 522 launch posts from 52 labs, and none of them list this benchmark. Some system cards do, below.

19 system cards report it, from 5 labs

Besides launch posts, we read the system cards, model cards and technical reports labs publish with a release. They report far more, including safety and frontier-risk tests.

DateDocumentScoreAs the document writes itSection
Oct 23, 2026 Muse Spark 1.3 system card 87.7 LAB-Bench ProtocolQA accuracy, Muse Spark 1.3 (API) (Table 1, Figure 2) Bio and chem risk
Oct 12, 2026 Muse Wonder Full model card 89 Lab-Bench (v1) ProtocolQA (CBRN Capability Evaluations table, section 4) Bio and chem risk
Jul 9, 2026 Muse Spark 1.1 system card 88 LAB-Bench ProtocolQA, Muse Spark 1.1 Helpful (Table 1, Figure 3) Bio and chem risk
Jun 12, 2026 Muse Spark system card 87.3 LAB-Bench ProtocolQA (Table 1, Figure 3) Bio and chem risk
Apr 7, 2026 Grok 4.20 model card 79 ProtocolQA, accuracy 0.79, Grok 4.2 SA (human baseline 0.79) Bio and chem risk
Nov 24, 2025 Claude Opus 4.5 system card 90.7 LAB-Bench ProtocolQA, 10-shot, extended thinking, no tools, max across snapshots 0.907 (7.2.4.4) Bio and chem risk
Nov 18, 2025 Gemini 3 Pro system card 87.4 LAB-Bench ProtocolQA (N=108), mean solve rate, shuffled answer choices (Figure 1) Bio and chem risk
Nov 17, 2025 Grok 4.1 model card 79 ProtocolQA, accuracy 0.79, multiple choice, Grok 4.1 Thinking (Table 4) Bio and chem risk
Oct 15, 2025 Claude Haiku 4.5 system card 69 LAB-Bench ProtocolQA, k-shots=10, score 0.69 (6.2.3.1) Bio and chem risk
Sep 29, 2025 Claude Sonnet 4.5 system card 83.3 LAB-Bench ProtocolQA, 10-shot, no tools, score 0.833 (Figure 9.2.4.4.A) Bio and chem risk
Aug 5, 2025 Claude Opus 4.1 system card addendum 69 LAB-Bench subset ProtocolQA 0.69 (6.3.1.2) Bio and chem risk
Jul 7, 2025 Gemini 2.5 Pro technical report 74 LAB-Bench ProtocolQA (N=108), mean solve rate (Figure 9) Bio and chem risk
Jul 7, 2025 Gemini 2.5 Flash technical report 64 LAB-Bench ProtocolQA (N=108), mean solve rate (Figure 9) Bio and chem risk
May 22, 2025 Claude Sonnet 4 system card LAB-Bench ProtocolQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) Bio and chem risk
May 22, 2025 Claude Opus 4 system card LAB-Bench ProtocolQA, 0, 5 and 10 shots, extended thinking, chart without printed values (Figure 7.2.4.7.A) Bio and chem risk
Apr 28, 2025 Gemini 2.5 Pro model card 69 ProtocolQA (N=108), mean solve rate over 100 shuffled runs (Figure 1) Bio and chem risk
Feb 24, 2025 Claude 3.7 Sonnet system card LabBench subset ProtocolQA, 0 and 5 shots with Bo1 to Bo10, 32k thinking, chart without printed values (Figures 18 and 19) Bio and chem risk
Sep 12, 2024 o1-preview system card 81 LAB-Bench: ProtocolQA, final o1-preview model per text (near-final post-mitigation chart label 73.1% cons@32) (4.3.5) Bio and chem risk
Sep 12, 2024 o1-mini system card 67.6 LAB-Bench: ProtocolQA, pass rate cons@32, o1-mini (post-mitigation), printed chart label (4.3.5) Bio and chem risk

Versions

We switch the top row to each new version when it comes out. Open it for one row per version. An old version stays in play while people still test it, so whoever first takes it past 85% gets credit for closing it out.

OpenAI Anthropic Google DeepMind
LABBench2 ProtocolQA2 Not tested since Feb 2026
Gemini 3 Pro 61.6%
LAB-Bench ProtocolQA Passed 85% in Nov 2025, by Gemini 3 Pro
LABBench2 ProtocolQA2 Not tested since Feb 2026
Gemini 3 Pro 61.6%

Sources: Official leaderboards and labs’ model cards

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